hiv-1 protease-in-1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T63453	HIV-1 protease-IN-1
	HIV-1 protease-IN-1 is a potent inhibitor of HIV-1 protease (IC50: 90 pM). HIV-1 protease-IN-1 has antiviral activity against B-HIV (EC50: 89 nM): HIV-1 protease-IN-1 was able to act on C-HIV strain ZM246 (EC50: 13.59 nM...
T74939	HIV protease-IN-1
	HIV protease-IN-1 (compound 1·succinate), a potent non-peptidic inhibitor of HIV protease, is utilized for AIDS research [1].
T64112	HIV-1 protease-IN-5
	HIV-1 protease-IN-5 is an HIV-1 protease inhibitor (IC50: 1.64 nM). HIV-1 protease-IN-5 exhibits significant effects on wild-type and DRV-resistant HIV-1.
T63733	HIV-1 protease-IN-6
	HIV-1 protease-IN-6 (compound 17d) is a potent inhibitor of HIV-1 protease (IC50: 21 pM, Ki: 4.7 pM). HIV-1 protease-IN-6 showed significant antiviral activity against DRV (darunavir) resistant mutants, even exceeding th...
T79536	HIV-1 protease-IN-11		HIV Protease
	HIV-1 protease-IN-11 (compound 34a), an HIV-1 protease inhibitor, demonstrates potent inhibition with an IC50 of 0.41 nM and maintains substantial efficacy against drug-resistant variant [1].		HIV Protease
T79493	HIV-1 protease-IN-10		PKC
	HIV-1 protease-IN-10 (Compound 2), exhibiting HIV-1 latency reversing activity (IC50: 0.22 μM), selectively binds to the PKCδ C1b domain (IC50: 0.69 μM) and demonstrates stability against esterase-mediated hydrolysis [1]...		PKC
T63949	HIV-1 protease-IN-2
	HIV-1 protease-IN-2 is a potent inhibitor of HIV-1 protease (IC50: 2.53 nM). HIV-1 protease-IN-2 exhibits antiviral effects against DRV (Darunavir) sensitive or drug resistant HIV-1 mutants.
T79537	HIV-1 protease-IN-12		HIV Protease
	HIV-1 protease-IN-12 (compound 35b) serves as a potent inhibitor of HIV-1 protease, exhibiting an IC50 value of 0.51 nM, and demonstrates efficacy against drug-resistant variant [1].		HIV Protease
T74942	HIV-1 protease-IN-7		HIV Protease
	HIV-1 protease-IN-7 (compound 16) is an orally active inhibitor of HIV-1 protease, exhibiting an IC50 of 3.52 nM and an EC50 of 37 nM [1].		HIV Protease
T78950	HIV-1 protease-IN-8		HIV Protease
	HIV-1 protease-IN-8 (compound 34b) is a potent inhibitor of the HIV-1 protease enzyme, exhibiting an IC50 of 0.32 nM. It demonstrates IC50 values of 0.29 μM for the wild-type HIV-1 (HIV-1 NL4-3) and 1.90 μM against a dru...		HIV Protease
T79295	HIV-1 protease-IN-9		HIV Protease
	HIV-1 protease-IN-9 (compound 5b), a potent HIV-1 protease inhibitor, exhibits strong antiviral efficacy with a dissociation constant (K_i) of 0.028 nM and a half-maximal inhibitory concentration (IC_50) of 66.8 nM [1].		HIV Protease
T74488	HIV-1 protease-IN-4
	HIV-1 protease-IN-4 (Compound II-22), a potent inhibitor of the HIV-1 protease, acts as a prodrug for atazanavir. It notably enhances the bioavailability of atazanavir in rat plasma, achieving a 5-fold increase in the ar...
T3335	Darunavir Ethanolate	UIC 94017,Darunavir Ethanolate,TMC114	HIV Protease
	Darunavir Ethanolate (UIC 94017) is an HIV PROTEASE INHIBITOR that is used in the treatment of AIDS and HIV INFECTIONS. Due to the emergence of ANTIVIRAL DRUG RESISTANCE when used alone, it is administered in combination...		HIV Protease
TN1059	Ganoderic acid B		IL Receptor , HIV Protease , JAK , STAT
	Ganoderic acid B is a chemical marker in quality control of G. lucidum and related products. Ganoderic acid B-containing herbs has potential influence towards therapeutic window of trifluoperazine.Ganoderic acid B has an...		IL Receptor , HIV Protease , JAK , STAT
T76603	HIV-IN petide
	HIV-IN petide is a competitive inhibitor of HIV-1 protease (K i =50 nM) [1] .
T70491	XM 323
	XM 323 is an inhibitor of clinical isolates of HIV-1 in vitro and represents a novel class of non-peptidyl inhibitors of HIV-1 protease.
T28306	PD 099560	PD099560,PD-099560
	PD 099560 is a non-peptide inhibitor of HIV-1 protease, a significant target enzyme in AIDS research.
T28811	SM111	SM 111,SM-111
	SM111 inhibits in vitro replication of HIV-1, including strains resistant to reverse transcriptase, licensed protease, and integrase inhibitors, without major cellular toxicity.
T39345	Lopinavir Metabolite M-1
	Lopinavir Metabolite M-1, an active metabolite derived from Lopinavir, effectively inhibits the HIV protease enzyme with a Ki value of 0.7 pM. Additionally, in vitro studies have revealed notable antiviral properties ass...
T76512	Ac-Ser-Gln-Asn-Tyr-Pro-Val-Val-NH2
	Ac-Ser-Gln-Asn-Tyr-Pro-Val-Val-NH2 is a peptide substrate specific to HIV-1 protease, serving as the variable component in peptidolytic assays designed to measure the enzyme's inhibition [1] [2].